The Translational Neuroengineering Lab (tnelab.org) is testing a novel approach to treating Treatment-Resistant Depression (TRD) through Deep Brain Stimulation (DBS). This treatment is offered through enrollment in an industry-sponsored multi-center clinical trial. Participants must have severe, treatment-resistant Major Depressive Disorder and have tried multiple therapies and medications with no relief before enrolling in this trial. We are testing various DBS approaches that work differently for patients with different symptom clusters. For more information, please contact the SLP clinic at 952-525-4500 or [email protected].